Russia has listed transsexual and transgender people among those who will no longer qualify for driving licences.
Fetishism, exhibitionism and voyeurism are also included as "mental disorders" now barring people from driving.
The government says it is tightening medical controls for drivers because Russia has too many road accidents.
"Pathological" gambling and compulsive stealing are also on the list. Russian psychiatrists and human rights lawyers have condemned the move.
The announcement follows international complaints about Russian harassment of gay-rights activists.
In 2013 Russia made "promoting non-traditional lifestyles" illegal.