First of all, the genetic/biological makeup of the serpent (The form Satan was using. See Revelation 12:9, 20:2) was altered (Genesis 3:14); the genetic/biological makeup of women was altered (Genesis 3:16); the genetic/biological makeup of plants were altered (Genesis 3:18), the ground was cursed so that it didn’t produce fruit, and in turn, would seem to prompt changes for the sake of survival in countless other organisms (Genesis 3:17).